Crosstown Center is located less than a mile from I-90's Albany Street exit (Exit 20) and just blocks from I-93's Southhampton Street exit (Exit 16). The complex is bordered by major Boston roadways Albany Street (west), Massachusetts Avenue (north) and Melnea Cass Boulevard (east).

From Longwood Medical Center:

7 minutes - 1.6 miles by way of Huntington and Massachusetts Avenues

From Back Bay:

6 minutes - 1.3 miles by way of Huntington and Massachusetts Avenues

From Financial District:

9 minutes - 2.2 miles by way of I-93 and Albany Street